ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .

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The radical scavenging activity of Vasicine acetate at different concentrations is shown in Table 3. Shade dried and coarsely powdered leaves of A.

Antibacterial Activity of Leaf Extracts of Adhatoda vasica – MAHE Digital Repository

Vasicine acetate showed minimum inhibitory concentration values against bacteria: The MIC for fungi was defined as the lowest extract concentration, showing no visible fungal growth after incubation time. Introduction Natural products still remain the most important source for discovery of new and potential drug molecules.

Handbook of Ayurvedic Medicinal Plants. The cytotoxicity was determined according to the method of Balachandran et al. The ethanol extract of A. Every year, at leastpeople die worldwide from cancer related to their workplace [ 3 ]. The mobile phase was filtered through a 0.

Ray of hope for cancer patients. Estimates of worldwide burden of cancer in Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness.

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Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Ignacimuthu and Shanmugam [ 15 ] have reported the antitubercular activity of Vasicine acetate isolated adhattoda A. Other constituents include vitamin C, saponins, flavonoids as well as steroids, and fatty acids [ 13 ]. Vasicine acetate exhibited good zone of inhibition against bacteria: All melting point values are uncorrected and taken by open capillary method on a heating block Instrument. Microbial Organisms The following Gram negative, Gram positive bacteria, clinical isolates, and fungi were used for the experiment: Abstract Activuty vasica L.

Vasicine acetate showed moderate antibacterial activity compared to Vasicine.

Antibacterial activity of adhatoda vasica leaf extract

The estimation of Vasicine acetate content in the extract was performed using linear regression analysis. The worldwide threat of antimicrobial resistance.

Antibacterial and antifungal activities were carried out using disc diffusion method [ 16 atnimicrobial. Indian Journal of Microbiology. Table 2 Minimum inhibitory concentration of Vasicine acetate against tested bacteria and fungi.

The combined chloroform adhatofa was washed with water, dipped, and dried over anhydrous sodium sulphate. Vasicine acetate was obtained by acetylation of Vasicine recovered from A. The plant was identified by Dr. Further elution of the column with chloroform: Structure of the compounds: Cytotoxic A and antimicrobial effects of Methylobacterium sp. Preliminary phytochemical and antibacterial screening of crude extract of the leaf of Adhatoda vasica.


Journal List Biomed Res Int v. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.

Antimicrobial Activity Antibacterial and antifungal activities were carried out using disc diffusion method [ 16 ]. Vasicine hydrochloride, a new drug for interruption of pregnancy. Al-Dhabi1 C. Minimum Inhibitory Concentration MIC Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ]. The emergence of drug-resistant pathogens and the increase in diseases affecting the immune system have greatly intensified activjty need to investigate new bioactive metabolites for potential pharmaceutical and industrial applications [ 12 ].

Clinical and Laboratory Standards Institute; B revised New Delhi, India: Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals.

Medicinal plants are important sources of practical drugs for people throughout the year. The vasicz Gram negative, Gram positive bacteria, clinical isolates, and fungi were used for the experiment: Anyimicrobial plant is used in the indigenous system of medicine in India and is a well-known expectorant in both Ayurvedic and Unani Systems of Medicine [ 45 ].

Vasicine acetate showed antimycobacterial activity [ 15 adhatodx.

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